Simulated gastric hydrolysis and developmental toxicity of dimethyltin bis(2-ethylhexylthioglycolate) in rats – Dr Dominik Kirf is first author of a scientific article published in Frontiers of Toxicology
Dr Dominik Kirf (Chemservice S. A. Luxembourg) with the support of his team and other experts in the field, has recently published a paper on simulated gastric hydrolysis and developmental toxicity of dimethyltin bis(2-ethylhexylthioglycolate) in rats.
Research described outlines an in vivo developmental toxicity study (OECD TG 414) and simulated gastric hydrolysis of an important organotin substance. More specifically, the substance dimethyltin bis(2-ethylhexyl thioglycolate) was assessed in rats to determine its fetal developmental toxicity and to compare the novel result with an existing read-across rational currently in use for the substance and similar organotin compounds. However, read-across as such is not without limitations in regulatory toxicology, issues with standardisation and a lack of comparative animal testing are at times overlooked in the read-across approach. This research together with previous peer-reviewed publications suggested that the read-across currently in use might not accurately predict the toxicity profile of important organotin compounds. As organotin compounds have many important applications it is considered imperative to establish accurate safety or toxicity profiles for these compounds.
The paper is available via the following link: